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doi: 10.1021/acs.jafc.6b02468 147

Neuroprotective effects of the allosteric agonist of metabotropic glutamate receptor 7 AMN082 on oxygen-glucose deprivation- and kainate-induced neuronal cell death

Inside hepatocytes, it immediately begins neutralizing free radicals and binding to toxins

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0.22 m) immediately prior to use Aliquot and store reconstituted solutions at 20 C (or lower) to minimise degradation Avoid repeated freezethaw cycles Due to reported low intrinsic stability in vitro, prepare fresh working solutions when possible Specifications Summary Precautions & Notes Experimental behaviour of DSIP is dependent on concentration, exposure duration, and model system Buffer composition, pH, and enzymatic activity may influence peptide stability Due to reported rapid degradation in some in vitro systems, appropriate controls are recommended Literature reports describe heterogeneous and sometimes contradictory findings across models Intended strictly for laboratory research use