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These data are in agreement with the observation that DSF on its own decreases H 2 S production, although with a limited effect, but has an increased effect (as well as increased toxicity) when combined to copper (Supplementary Figures 2A, B)

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Significantly, enhanced transamination and aspartate synthesis in K-Ras-driven cancer cells are important in the promotion of nucleotide biosynthesis 184 and maintenance of redox balance 29

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