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Tirzepatide is a medication that combines two hormone actions: GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide)

It signals beta cells in your pancreas to release insulin and inhibits the secretion of glucagon, lowering blood sugar levels

The peptide is the trigger, not the effect itself

Absolute contraindications include: Personal or family history of medullary thyroid carcinoma (MTC) Multiple endocrine neoplasia syndrome type 2 (MEN2) Known hypersensitivity to the medication or its components These are based on boxed warnings and prescribing information and should be treated as non-negotiable