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Nutrient Bioavailability: Some research suggests that delayed digestion may reduce the absorption efficiency of certain micronutrients, such as fat-soluble vitamins (A, D, E, and K), which require bile and proper fat metabolism for uptake

Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to estimate reliably their frequency or establish a causal relationship to drug exposure

Skin irritation around the patch site

Allergic reactions, though infrequent, can include anaphylaxis with MB given intravenously

In a split-face trial performed in India, participants with facial melasma were prescribed twice-daily application of 20% azelaic acid cream to half the face for 24 weeks