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discovered that MWCNT instillation reduced the mRNA expression of CPT1, CPT2, and PPAR coactivator 1 alpha in permeabilized bronchoalveolar lavage cells, accompanied by elevated oxidative stress in alveolar macrophages and inflammatory injury of murine lung tissues (Huizar et al., 2013)

Since the net charge of CAND is -0.2, resulting in an overall neutral charge, it is difficult for CAND to be effectively transported to the cell nucleus on its own

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Deficiency of cytochrome b5 reductase, but not of NADPH-flavin reductase, is associated with methemoglobinemia, confirming that cytochrome b5 reductase is the most important physiologic means of reducing methemoglobin