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Moreover, the gut microbiota contributes significantly to bilirubin metabolism by influencing bile acid composition and enterohepatic recycling, further modulating gallstone risk and increasing the chance of gallstone formation

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121,122 Multiple lines of evidences have revealed that IDH1 is overexpressed in numerous cancers and is closely correlated with poor prognoses of patients with non-small cell lung carcinoma (NSCLC), 123 PDAC, 124 or one of several hematological malignancies

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Several studies have shown that PEA is effective in reducing symptoms of IBS, such as abdominal pain and bloating