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Metanx was administered to 15 week old ZDF and ZDF lean rats at either 4.87 mgkg -1d -1 (the dose used in clinical practice) or 24.35 mgkg -1d -1, 2 times a day, for 4 weeks

All the determinations were made in triplicate and presented as the mean of three values SD

5-Amino-1MQ formally 5-amino-1-methylquinolinium iodide is a small-molecule selective inhibitor of nicotinamide N-methyltransferase (NNMT)

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