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This work was supported by grants from the American Heart Association (RG: AHA916225, ANT: and ST: AHA CDA941290, SSC: the National Institute on Aging (RF1 AG072295, R01 AG055395, R01 AG068295, R01 AG070915, K01 AG073614, K01 AG073613, R03 AG070479, R21 AG080775 - 01 A1), the National Institute of Neurological Disorders and Stroke (R01 NS100782), and the National Cancer Institute (R01 CA255840)

After initial sensitization, re-exposure to allergen results in IgE crosslinking with Fc R1 receptors, leading to mast cell and basophil degranulation of histamine, leukotrienes, and prostaglandins, which go on to promote bronchoconstriction