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The mechanisms underlying 3-HK toxicity remain incompletely defined, but its strong propensity for oxidation makes it a potent generator of ROS

eNOS uncoupling is caused by deficiency or oxidation of tetrahydrobiopterin, an important cofactor for eNOS action, leading to increased generation of superoxide and decreased NO bioavailability (155)

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The speed and effectiveness of this response play a crucial role in determining the future fate of the plant host (Yadav, 2010)

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