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CAN is characterized by damage to the nerve fibers that innervate the heart and blood vessels, leading to reduced heart rate variability (variability in the time interval between heartbeats) and increased risk of mortality (80)

Therapeutically, iron chelator desferrioxamine has already been conducted a clinical trial in AD in 1991 (Crapper McLachlan et al., 1991)

While many antioxidants come solely from the food we eat, the body creates its own supply of glutathione, primarily in the liver

In summary, nanoencapsulation in nutraceuticals has evolved from simple protective concepts into sophisticated, multifunctional delivery systems