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Johansen, O

The mechanism of action, particularly BDNF upregulation, neuroplasticity enhancement, and microglial optimization, is theoretically supportive of cognitive enhancement in healthy brains

This heterogeneity may stem from differences in intervention duration, baseline health conditions, as well as the varying severity of depression and anxiety across study populations, which limited our ability to perform subgroup analyses based on baseline disease severity

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Simultaneously, these bacteria-free animals have an underdeveloped intestinal mucosal immune system and systemic immunological modifications, including a marked decrease in T helper cells in the spleen