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Comparable age groupings are proposed in the Dietary Guidelines for Americans, though the recommended intake levels differ, beginning at 0.5 g in infancy, increasing to 2.4 g for adults, and rising modestly during pregnancy and lactation (2.6 g and 2.8 g, respectively

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Experimental evidence from knockout models suggests that reduced NNMT activity is associated with resistance to tumor formation, leading to speculation about a possible role for this enzyme in cancer biology