The incidence is approximately 0.4% at doses up to 450mg daily, which sounds small until you realize that certain conditions dramatically increase this baseline risk
Dalkara T, Ostergaard L, Heusch G, Attwell D (2024) Pericytes in the brain and heart: functional roles and response to ischemia and reperfusion
This suggests that for many people, the medication acts as a catalyst for improving heart health rather than a direct threat to it
NAPQI Formation Highest in FIRST Trimester 43% HIGHER The same Brookhuis 2021 study found: The estimated molar dose fraction of NAPQI was the highest in the first trimester (median (IQR): 11 (9.113.4%), followed by the second (9.0 (7.511%)) and third (8.2 (6.810.1)) trimester compared with non-pregnant women (7.7 (6.49.4%)).[] **This represents a 43% INCREASE in toxic NAPQI formation in the first trimester** (11% vs 7.7%)precisely when the fetal brain is most vulnerable and undergoing critical early development
In this respect, our literature review confirms the attractiveness of ARs transcription factor moiety and highlights the relevance therein for two of its major determinants, its protein interactome and its DNA binding sites, for context-dependent transcriptional regulation of AR target gene expression
