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Sustained IGF-1 elevation is a theoretical concern for occult malignancy and for proliferative retinopathy, and most research protocols include a baseline and a 12 week IGF-1 measurement with dose reduction or discontinuation triggers at greater than 2 standard deviations above the age-matched mean

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For example, compared to individuals without these inflammatory conditions, patients with psoriatic arthritis have a 90% higher risk of hypertension [203], those with rheumatoid arthritis have a 50% higher risk [204], and individuals with periodontitis have a 22% increased risk of hypertension [205]

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(2021) 11:e043054