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Strikingly, estrogen deprivation was shown to be the principal mediator of impaired wound healing in the elderly population when a microarray study revealed that 78% of genes differentially expressed between wounds from young and aged men were estrogen-regulated, while only 3% were related to intrinsic aging (Hardman and Ashcroft, 2008

Most people say it feels like a quick mosquito bite, barely noticeable

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Jul 3 2007;147(1):19-27

However, similar to the susceptibility to idiopathic disc degeneration, spine trauma does not cause posttraumatic degeneration and loss of disc function in every patient even in the presence of an endplate fracture