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Fasting triggers a cascade of metabolic benefits, including: Increased insulin sensitivity Enhanced GLP-1 secretion Reduced appetite and cravings Improved fat burning Studies show that even short fastslike a 12- to 16-hour fasting windowcan elevate GLP-1 and improve metabolic flexibility

276 By contrast, Fagher et al 308 found no subjective improvement in fatigue in 14 patients treated with L-carnitine for 6 weeks

No peptide compensates for inadequate protein intake or absent resistance training, and the lean mass benefit these therapies are prescribed for depends on a training stimulus to act on

After he published a series of animal and cell studies on humanins potential benefitsthe peptide seemed to curb inflammation, control glucose, and possibly even provide protection against Alzheimersso-called biohackers began ordering it on the gray market

First dedicated kidney-outcomes RCT of a GLP-1RA, showing a 24% reduction in major kidney events