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8,129,343 are the two key patents that disclose the composition of semaglutide, the active ingredient in Ozempic, Wegovy, and Rybelsus

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Step 4: Preparation of compound of formula-13 The reaction mixture obtained in step 3 was slowly added to a mixture of ethanol (150 ml), DIPEA (11.68 ml) and 2-(2-(2-aminoethoxy)ethoxy)acetic acid compound of formula-10 (9.23 gm) at 25-30C and stirred the reaction mixture for 90 min at the same temperature