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GLP-1RAs improve glucose uptake in cardiomyocytes through dual mechanisms: triggering AMPK activation to facilitate GLUT4 translocation to the cell membrane and regulating the insulin signaling pathway to upregulate GLUT4 expression (79, 80)

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Tardive dyskinesia (more common with metoclopramide than domperidone) and QTc (corrected QT interval) prolongation with the potential for arrhythmia are important concerns, although the risk of tardive dyskinesia may be as low as 0.1% per 1000 patient-years with metoclopramide [71]