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Furthermore, GPNA inhibits the transport activity of SLC1A5_var [36]

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24 One hypothesis is that chronic GIP R agonism results in functional antagonism due to desensitisation to ligand-mediated stimulation

For instance, pancreatic-targeted nanocarriers co-delivering GLP-1 and IL-10 plasmids provided dual metabolic and immune benefits in type 1 diabetes models, where GLP-1R activation restored islet function while IL-10 induced immune tolerance [431]

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