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The study was the first to report an association between semaglutide and a higher risk of NAION, although further studies (such as a larger, multicenter study or prospective clinical trials) are required to confirm findings and determine causality

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However, the prospective Shanghai Osteoarthritis Cohort study showed that GLP-1RA users with KOA and diabetes exhibited a greater reduction in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) total and pain score and a lower occurrence of knee surgery compared to controls

However, the agency wont take immediate action against pharmacies in order to avoid unnecessary disruption to patient treatment, according to a statement

Table 1 Landmark GLP-1 receptor agonist trials and renal eligibility