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At age 20, plasma concentrations average approximately 200 ng/mL

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GLP-1 receptor agonists are medications that mimic the action of the natural hormone glucagon-like peptide-1

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However, exogenous IGF-1 LR3 suppresses endogenous GH secretion via negative feedback, so the GH secretagogue effect is partially blunted during active IGF-1 LR3 dosing the optimal strategy uses IGF-1 LR3 during the active cycle and transitions to GH secretagogues during the washout period

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doi: 10.1016/j.jep.2016.05.010

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