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"So it's another piece of the pie, another proof of evidence that the semaglutide is working on those systems in the brain that we know are important for addiction." Leggio is now working on a protocol for a randomized controlled trial that will look at semaglutide and alcohol use in humans and collaborating with Oklahoma State University on a similar study
The authors re-analysed the data from the phase 2 trial and concluded that the ER formulation may be more effective in achieving target engagement, therefore proposing a longer study with higher doses (i.e
Ma J, Zhang Z, Li S, Chen X, Wang S
Participants were allocated in a 21:3:3:7 ratio to weekly injections of one of four regimens: fixed-dose cagrilintide 2.4 mg plus semaglutide 2.4 mg, semaglutide alone, cagrilintide alone, or placebo