[1] [3] Importantly, patients should seek urgent medical attention if they experience severe or persistent abdominal pain (especially if radiating to the back), repeated vomiting, inability to keep fluids down, signs of dehydration, or jaundice, as these may indicate serious conditions such as pancreatitis or gallbladder disease
It has a favorable topical tolerability signal in cosmetics and preclinical models, but there is no published human trial quantifying its side effects, and no systemic/injectable safety data at all
Some of the most severe side effects, such as angle-closure glaucoma, may evolve into chronic and lifetime conditions
Most people find these effects are strongest when starting the medication and tend to improve as their body adjusts
This process allows them to create doses, concentrations, and formulations that may differ from the standardized brand-name products