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No Rebound Hunger or Metabolic Adaptation Appetite suppressants that work through central mechanisms (GLP-1 agonists, sympathomimetics, serotonergic agents) typically create tolerance over time, requiring dose escalation, and often produce rebound hunger when discontinued

Dose adjustments are made based on symptoms and sensitivity under a clinicians guidance

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10.5455/njppp.2016.6.2709201591 17 ChoiE