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19 Safety Profile and Regulatory Status Allulose has received Generally Recognized as Safe (GRAS) designation from the U.S

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The proposed direct vascular mechanisms, supported by preclinical and clinical data, include the following: Endothelial protection: GLP-1 receptor agonists promote nitric oxide production, vasodilation, and angiogenesis while inhibiting oxidative stress in vascular endothelial cells Plaque stabilization: Reduced matrix metalloproteinase activity prevents fibrous cap degradation

For research purposes, the cancer-related concerns suggest several precautions