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Assuming that stable mutant monomers are synthesized, up to seven different tetrameric forms of PK may be present in compound heterozygous individuals, each with distinct structural and kinetic properties

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Dose reduction or temporary treatment interruption may be necessary in some cases

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FDA has approved metformin for managing Type 2 diabetes, and healthcare providers frequently utilize it off-label for a variety of other conditions, including addressing weight gain associated with certain medications, managing gestational diabetes, preventing the onset of Type 2 diabetes in high-risk individuals, and treating PCOS