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Adverse Effects and Long-Term Safety Concerns While GLP-1 receptor agonists have shown significant benefits, their widespread use is limited by potential side effects such as gastrointestinal distress, pancreatitis risk, and concerns over long-term metabolic effects

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On top of these administrative hurdles, drug shortages have plagued the market, making it difficult for patients to start or continue treatment

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Actual costs may be lower with private insurance, Medicare, or savings programs, if prescribed for diabetes, heart, or kidney conditions