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The animal data is real, extensive, and consistently positive across multiple injury and disease models

Targeted inhibition of NNMT improves insulin responsiveness and may protect against diet-induced obesity. Hong et al., Nature Medicine Longevity and Anti-Aging Potential Because NAD is vital for DNA repair, circadian rhythm regulation, and mitochondrial health, 5-Amino-1MQ is being explored as a geroprotective agent especially when stacked with NAD boosters or sirtuin activators

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A transient breach in the epithelial barrier leads to regulatory T-cell generation and resistance to experimental colitis