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In models stimulated by the inflammatory cytokine IL-1, PBM significantly suppressed the expression of key matrix-degrading enzymes (such as ADAMTS5 and MMP-13) and the pro-inflammatory factor TNF- (44)

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Hormones play critical roles in coordinating cellular activities throughout the body in response to the constant changes in both the internal and external environments

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First-in-human clinical trials, also known as FIH trials, are studies during which a drug is administered to humans for the first time after its testing in in vitro and in vivo preclinical, experimental models