Instead, it excretes any excess B12 through urine, which means you must regularly consume foods or supplements that contain B12 to maintain adequate levels in your body
Whats unique about GLP-1 agonists is that we already have a lot of experience with them in patients with diabetes
1 CT-388 is currently being evaluated in an additional Phase II study, CT388-104, designed to assess its efficacy, safety, and tolerability in participants living with obesity or overweight who also have type 2 diabetes
An in vitro study in hCAECs found that exenatide decreased inflammation by reducing activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B), adhesion molecules intracellular adhesion molecules (ICAM) and vascular cell adhesion molecules (VCAM), but not P-selectin (Garczorz et al., 2018)
What other treatments are there