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Acute symptoms such as fatigue may improve within days, whilst neurological symptoms like paraesthesia typically require weeks to months of treatment

Drinking too much alcohol and becoming intoxicated can impair the immune system so that the vaccine doesnt work as well as it normally would

You might be suffering the symptoms of B12 deficiency, or you might know that you are at increased risk of B12 deficiency as a result of hereditary factors or other health conditions

If these develop while taking supplements, they warrant medical assessment to rule out ongoing deficiency or other neurological conditions

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