However, despite clinical efficacy of GLP-1RAs, clinical data has highlighted increased risk of gallbladder disease, including gallstone formation (cholelithiasis), inflammation of the gallbladder (cholecystitis), and pancreas, especially with higher doses and prolonged use (1,5,6)
There is no current evidence that local resection of posterior uveal melanoma is different from enucleation or radiotherapy with regard to patient survival

Abbreviations AEs: adverse events BC: body composition BHB: -hydroxybutyrate BIA: bioelectrical impedance analysis BIVA: bioelectrical impedance vector analysis BMI: body mass index BW: body weight CT: computed tomography CVD: cardiovascular disease FM: fat mass FFM: free fat mass GI: gastrointestinal GLP-1: glucagon-like peptide-1 GLP-1RA: glucagon-like peptide-1 receptor agonist HFpEF: heart failure with preserved ejection fraction KD: ketogenic diet LBM: lean body mass MASH: metabolic dysfunction-associated steatohepatitis MD: Mediterranean diet MEAL: Muscle maintenance, Energy balance, Avoid side effects, Liquid intake MM: muscle mass MNT: medical nutrition therapy MRI: magnetic resonance imaging PUFA: polyunsaturated fatty acids RCTs: randomised controlled trials SCFAs: short-chain fatty acids STEP: Semaglutide Treatment Effect in People with obesity T2D: type 2 diabetes TNF: tumor necrosis factor VLCKDs: very-low-calorie ketogenic diets VLEKT: very low energy ketogenic therapy WC: waist circumference WHO: World Health Organization References Finucane MM, Stevens GA, Cowan MJ, Danaei G, Lin JK, Paciorek CJ, et al

Patients who have switched to other glucose-lowering medicines during the shortage but still have a valid GLP-1 therapy prescription such as Ozempic should consult their doctor for guidance
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