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Maladaptive trained immunity is innate immune cells acquiring non-specific inflammatory memory via metabolic, transcriptional and epigenetic reprogramming of bone marrow HSPCs after microbial or inflammatory stimulation, with high reactivity upon re-stimulation

For example, one study utilized enteric glial cells as an astrocyte source and examined the improvement in neuropathology and cognitive function following transplantation 130

Here we report on Spirulina platensis (SP), a natural microorganism commercially farmed worldwide as a food, as an efficient regulator of both synovial inflammation and osteoclast differentiation in male RA mouse models

Demographic and clinicopathologic characteristics were abstracted from medical records

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