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3g), hold potential translational value

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Unlike insurance claims data, which tend to reflect usage among diabetic or obese patients with treatment covered by insurance, Numerators data also capture households that use GLP-1 drugs off-label, including many who pay out of pocket and do not meet the clinical criteria for obesity, providing a broader view of adoption patterns

One study demonstrated that less than a third individuals achieved greater than 5% weight loss during the three-year study period and only 25% of these individuals were able to maintain greater than 5% weight loss

While gastrointestinal side effects like nausea and constipation dominate the conversation around tirzepatide tolerability, some patients report muscle-related discomfort during treatmentraising important questions about frequency, severity, and management options