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Retatrutides safety profile is consistent with whats already been observed GLP-1 receptor agonists and combined GLP-1/GIP receptor agonists, meaning the expected side effects are primarily gastrointestinal (GI) in nature: Nausea, vomiting, diarrhea, and constipation

Conversely, residues within positions 4552, except for residue 49, did not exhibit a notable increase in the hetNOE value

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Tirzepatide, like other GLP-1 agonists , also comes with side effects

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