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Whereas first-generation vaccines rely mainly on spike, there is strong evidence that adaptive immunity to nonspike antigens contributes to protection from infection and disease in natural infection

Mechanisms underlying the development of leptin resistance include gene mutations that encode leptin and its receptors, proteins involved in the self-regulation of leptin synthesis, and even factors that alter blood-brain barrier permeability

Cecal microbiota composition differs under normal and high ambient temperatures in genetically distinct chicken lines

Patients groups are then defined by time-dependent development of irAEs, such as before and after the landmark, with clinical outcomes only considered if occurring after the landmark [23]

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