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Ezrin expression and activation in hypertrophic and keloid scar

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Sulforaphane was the first identified and most potent naturally occurring NRF2 activator found in cruciferous vegetables such as broccoli, cauliflower, and Brussel sprouts (Zhang et al., 1992

In vitro studies have demonstrated that GHK-Cu increases the production of metalloproteinases and their inhibitors (TIMPs), enabling coordinated matrix remodeling rather than simply increasing matrix deposition