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Aberrations in multiple molecular pathways contribute to the development and progression of AD pathology including tau hyperphosphorylation, DNA hypomethylation, and maladaptive neuroinflammation (3)

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1) SGLT-2 , 2) GLP-1, , 3) dual-agonist, triple-agonist

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Analysis of tissue samples found that GLP-1 receptor proteins were most numerous in the pancreas, consistent with the drugs' known benefits in diabetes, but the heart had the second-highest concentration

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