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Finally, mutant p53 GOF activities, including the facilitation of cell proliferation, invasion, survival, cancer-promoting metabolism, protumorigenic inflammation, and drug resistance, have been observed in a series of experimental models, and multiple GOF mechanisms have been proposed

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Its proposed mechanism inhibition of tyrosinase and a resulting shift from eumelanin to phaeomelanin synthesis is used to support gradual, systemic skin brightening and hyperpigmentation reduction, though individual results vary

The total radioactivity concentrations in the intestine, skin, and lungs were similar to those in the plasma, and the mean concentrations in the gonads, myocardium, skeletal muscle, brain, and body fat were all lower than the mean concentrations in the plasma

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