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But the sentence that matters most for dosing is their conclusion that in most experimental situations, indications for bell-shaped dose-response curves of DSIP were found. [5] A bell-shaped (non-monotonic) dose-response means the effect rises to a peak and then declines as dose increases further

Proc Natl Acad Sci U S A 117(51):3237032379

The cytokine/chemokine pattern persisting at the inflammatory site is important in the development of chronic disease

This multi-layered approach to Notch pathway inhibition represents a particularly effective strategy given the pathways crucial role in cell fate decisions

Notably, TB-500 has been posited to exert positive actions on cellular regeneration by interacting with cellular mobility and thus supporting angiogenesis