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The most significant published evidence to date comes from a phase 2 randomised controlled trial (Jastreboff et al., New England Journal of Medicine , 2023), which demonstrated substantial dose-dependent weight loss in adults with obesity over 24 weeks, with continued weight reduction observed at 48 weeks

Choose Mounjaro if: You have insulin resistance, high visceral fat, or have stalled on other diets

This neurosteroid is synthesized in the brain, and higher concentrations are found in the brain than in plasma (123)

Sensitive individuals may start lower, but 1 mg remains the standard maintenance floor