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Across the cagrilintide clinical program, the dominant tolerability issues have been gastrointestinal: nausea, reduced appetite, constipation, and, less commonly, vomiting a profile shared with pramlintide and with GLP-1 agonists, and mechanistically expected from a compound that slows the stomach and engages the area postrema

A 2020 meta-analysis of 37 trials found L-carnitine supplementation reduced body weight by 1.21 kg, BMI, and fat mass, especially at 2,000 mg daily, when combined with diet and exercise

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Supplements replace proper nutrition No supplement replaces a balanced diet, regular activity, and consistent training