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Importantly, the ferroptosis suppressor protein 1 (FSP1)-coenzyme Q10 (CoQ10)-nicotinamide adenine dinucleotide (Phosphate) [NAD(P)H] and tetrahydrobiopterin (BH4)-dihydrofolate reductase (DHFR) pathways, though functioning independently, complement each other and, alongside GPX4 and glutathione, play crucial roles in preventing phospholipid peroxidation and, consequently, ferroptosis [114,115,116]
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General best practices include: Using only as directed for topical cosmetic use Avoiding contact with eyes or broken skin Discontinuing use if irritation occurs Storing properly to maintain stability These steps help ensure a safe and informed experience
The administration of GSPs not only improved nerve conduction velocity but also reduced markers of OS in diabetic models ( 4.5 Protection of mitochondrial function Mitochondria are critical for energy production and are also a major source of ROS
