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Central nervous system effects: The ability of SLU-PP-332 to cross the blood-brain barrier more readily may make it a better candidate for neurological indications

Abbreviations A: Amyloid AD: Alzheimers disease BBB: Bloodbrain barrier CSF: Cerebrospinal fluid CV: Cardiovascular FDA: US Food and Drug Administration GLP-1: Glucagon-like peptide-1 GLP-1RA: Glucagon-like peptide-1 receptor agonist hs-CRP: High-sensitivity C-reactive protein MACE: Major adverse cardiovascular event MCI: Mild cognitive impairment OD: Once daily OW: Once weekly p-tau: Phosphorylated tau s.c.: subcutaneous T2D: Type 2 diabetes References Scheltens P, De Strooper B, Kivipelto M, Holstege H, Chtelat G, Teunissen CE, et al

The results of meta-regression indicated a significant association between SBP reduction differences and the variety of control groups ( P 0.05)