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A second MDL involves sudden vision changes, optic nerve damage, loss of peripheral vision, blurred vision, or permanent blindness allegedly associated with NAION following semaglutide use

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Nat Rev Gastroenterol Hepatol (2019) 16(1):718

Additionally, 40.4% of individuals treated with CagriSema achieved a weight loss of 25% or greater after 68 weeks, in contrast to 6.0% with cagrilintide 2.4 mg, 16.2% with semaglutide 2.4 mg, and just 0.9% with placebo

This neurobiological rebound is not a willpower failureit reflects how deeply these medications alter hunger-regulating pathways in the hypothalamus and nucleus accumbens