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Several long-acting GLP-1 RAs have demonstrated CV protection in a dedicated CV outcome trial (CVOT) [7,8,9,10, 38] while the SURPASS-CVOT study (NCT04255433) for tirzepatide is ongoing and will provide further insights into whether these effects on blood pressure lowering, improvements in metabolic parameters and elevation in heart rate would combine to produce any meaningful impact on hard CV outcomes

Thyroid medications like levothyroxine should be taken at their usual time (typically first thing in the morning on an empty stomach) and may not be significantly affected, but monitoring thyroid levels during the first few months of tirzepatide treatment ensures adequate absorption continues

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Will my insurance cover tirzepatide if semaglutide did not work

These calculations are based on a 100-unit insulin syringe where 1 mL equals 100 units