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In a recent study of outpatients with ILDs, including IPF, depression score, functional status (as assessed by walk test), as well as pulmonary function, all contributed to the severity of dyspnea

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This is often attributed to an increase in time spent in REM sleep, which is the stage of sleep where most dreaming occurs and cognitive recovery happens

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Following discovery of a sparse number of occurrences of progressive multifocal leukoencephalopathy (PML) in those taking a FAE, median duration of FAE therapy to PML symptom onset or appearance of first PML brain lesion was 31 months (range 6110), with median duration of lymphocytopenia to PML symptoms being 23 months (range 672)