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For example, a recent meta-analysis of two randomized controlled trials showed that SGLT2i significantly reduced N-terminal B-type ANP (NT-proBNP) levels compared with placebo [57, 58], although Ueda et al

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doi: 10.3389/fimmu.2025.1639196 Received 01 June 2025 Accepted 17 September 2025 Published 03 October 2025 Volume 16 - 2025 Edited by Haibo Dong, University of North Carolina at Greensboro, United States Reviewed by Dawit Tadese, Ethiopian Institute of Agricultural Research (EIAR), Ethiopia Ji Sun, China Medical University, China Xiaoliang Gao, Fourth Military Medical University, China Updates Copyright 2025 Wang, Duan, Zhao, Zhang, Yu and Zhao