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These findings clearly show that GPX1 is irreplaceable by other selenoproteins in protecting against systemic oxidative stress, and GPX1 has a significant antioxidant function in the body ( FIGURE 1 On the surface, the mice after GPX1 KO performed normally, but these mice were susceptible to the production of oxidative substances, and when stimulated, they were easy to cause harm to mice and increase oxidative stress in vivo

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In addition, due to the ability of metformin to cross the placenta, continued use of metformin for GDM during pregnancy still raises concerns about its safety and potential adverse effects on the fetus

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