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[15] However, more research is needed to determine the complex interaction between genetic makeup and overall UV exposure

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Therefore, particular interest lies in elucidating the molecular and functional changes occurring in -cells and other islet endocrine cells in T2D, as these cellular adaptations and dysfunctions constitute the foundation of disease pathogenesis and provide a rationale for the development of targeted therapeutic strategies

J Clin Endocrinol Metab 76 : 309317 Kim KR et al

Elevated plasma and platelet cGAMP levels in cecal ligation and puncture (CLP)-operated mice activate STING palmitoylation by stimulating its interaction with STXBP2, triggering SNARE complex formation, granule secretion, and platelet activation